The San Francisco 49ers will seek their seventh consecutive victory when they visit the NFC West-rival Seattle Seahawks on Thursday Night Football. San Francisco (9-4) has ridden its winning streak to the top of the division and can clinch its second title in four years with a victory over Seattle, which it defeated 27-7 at home in Week 2. The Seahawks (7-6), who trail the 49ers by two games with four to play, have lost three of their last four overall contests and two straight at home after dropping a 30-24 decision against Carolina last week.
Kickoff from Lumen Field is set for 8:15 p.m. ET. San Francisco is a three-point favorite in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, while the over/under for total points scored is 43. Before making any Seahawks vs. 49ers picks, you need to see the NFL predictions and betting advice from SportsLine’s Advanced Computer Model.
The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks.
The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on 49ers vs. Seahawks and just locked in its picks and Thursday Night Football predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Seahawks vs. 49ers:
- 49ers vs. Seahawks spread: San Francisco -3
- 49ers vs. Seahawks over/under: 43 points
- 49ers vs. Seahawks money line: San Francisco -190, Seattle +158
- SF: 49ers are 2-8-1 against the spread in their last 11 games at Seattle
- SEA: Seahawks are 8-2-2 ATS in their last 12 Thursday contests
- 49ers vs. Seahawks picks: See picks here
Featured Game | Seattle Seahawks vs. San Francisco 49ers
Why the 49ers can cover
San Francisco hasn’t skipped a beat offensively since losing quarterback Jimmy Garoppolo to a broken foot in Week 13 as Brock Purdy has filled in effectively. The 22-year-old, who was the last player selected in the 2022 NFL Draft, tossed two touchdown passes against Miami after replacing Garoppolo and threw another pair while also running for a score in last week’s 35-7 rout of Tampa Bay. Purdy has completed 70.7% of his attempts and posted a 105.2 passer rating over 7 1/2 quarters as the team’s starting quarterback.
Running back Christian McCaffrey will be a major part of the offensive game plan. The 26-year-old has averaged 113.3 scrimmage yards during San Francisco’s winning streak, recording three rushing TDs and three receiving scores in that span. McCaffrey posted his first 100-yard rushing performance (119) as a 49er last week and also registered both a rushing and receiving touchdown for the 11th time in his career, tying Hall-of-Famer Jim Brown for fourth place on the all-time list. See which team to pick here.
Why the Seahawks can cover
Seattle has not been routed since the first meeting with San Francisco, with each of its following five losses being by seven points or fewer. The Seahawks are sixth in the NFL in scoring with an average of 26.3 points and have produced at least 24 in six of their last seven contests. Geno Smith has been a pleasant surprise for the team after winning the starting quarterback job following the offseason trade of Russell Wilson and is among the league leaders in a number of categories.
Smith, who last was a starting quarterback in 2014 with the New York Jets, leads the NFL in completion percentage (71.5%), ranks third in passer rating (106.8) and is fourth in both yards per attempt (eight) and touchdown passes (25). The 32-year-old has made multiple TD tosses in a league-high 11 games this season, including each of his last seven. Wideout Tyler Lockett has hauled in a scoring pass in a franchise-record six straight contests and is first on the team in both touchdown catches (eight) and receiving yards (896). See which team to pick here.
How to make 49ers vs. Seahawks picks on TNF
SportsLine’s model is leaning Over the point total, calling for 44 combined points. The model also says one side of the spread hits in over 50% of simulations. You can only see the model’s TNF picks at SportsLine.
So who wins Seahawks vs. 49ers on Thursday Night Football? And which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the Seahawks vs. 49ers spread you need to jump on, all from the model on a 157-113 roll on NFL picks, and find out.
